2009 Annual Meeting

ASENT's 11th Annual Meeting

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Thursday, March 5, 2009

Welcome

Title Speaker(s) Duration Presentation Audio Video
Welcome Roger Porter, M.D. and Larry Alphs, Ph.D. 6 min. 55 sec.     Video

Methodological Issues in Examining Cognition Across CNS Disorders

Title Speaker(s) Duration Presentation Audio Video
Cognition as an Under-Explored Aspect of Multiple Disorders Richard Keefe, Ph.D., Duke University Medical Center 4 min. 37 sec. Presentation   Video
Cognitive Assessment in Schizophrenia Clinical Trials: MATRICS and Beyond Michael F. Green, Ph.D., David Geffen School of Medicine at UCLA 24 min. 50 sec. Presentation   Video
Psychometric Considerations and Consensus Standards for Cognitive Testing in MS Ralph HB Benedict, Ph.D., SUNY Buffalo 25 min. 14 sec. Presentation   Video
Cognitive and Behavioral Endpoints as Primary Outcome Variables in Epilepsy Clinical Trials David W. Loring, Ph.D., Univeristy of Florida 24 min. 39 sec. Presentation   Video
Application of Cognitive Assessment Methods for Bipolar Clinical Trials Katherine E. Burdick, Ph.D., Albert Einstein College of Medicine 23 min. 37 sec. Presentation   Video
Panel Discussion Panel 1 hr. 31 min. 47 sec.     Video

Methodological Issues in Traumatic Brain Injury Research

Title Speaker(s) Duration Presentation Audio Video
Methodological Issues in Traumatic Brain Injury Summary   Presentation    
Introduction to Tramatic Brain Injury Alan Faden, M.D., Georgetown University Medical Center 8 min. 29 sec. Presentation   Video
MTBI In the Civilian Population: New Frontiers in Diagnosis and Treatment Mark R. Lovell, Ph.D., University of Pittsburgh 29 min. 50 sec. Presentation   Video
Characterization and Study of Acute Military Mild Traumatic Brain Injury in the War-Zone Col (S) Michael M. Jaffee, M.D., Defense and Veterans Brain Injury Center 29 min. 54 sec. Presentation   Video
Studies of Chronic Problems after Mild TBI in Military Populations: Challenges in the Characterization of Chronic Problems and Design of Treatment Trials Karen A. Schwab, Ph.D., Defense and Veterans Brain Injury Center 15 min. 21 sec. Presentation   Video
Questions and Answers Panel 15 min. 38 sec.     Video

Methodological Issues and Translation Research in Traumatic Brain Injury

Title Speaker(s) Duration Presentation Audio Video
Mild TBI: Animal to Human Translation Douglas H. Smith, M.D., Penn Center for Brain Injury and Repair 27 min. 42 sec. Presentation   Video
How Do We Optimise Neurotrauma Trial Design: Where Do We Go from Here? Ross Bullock, M.D., Ph.D., FRCS, University of Miami Leonard M. Miller School of Medicine 26 min. 2 sec. Presentation   Video

Dinner Symposium: Resource Allocation in Translation Neuroscience: Perspectives on Influencing the Pipeline

Title Speaker(s) Duration Presentation Audio Video
Resource Allocation in Translational Neuroscience Tom Insel, M.D., NIMH 15 min. 7 sec. Presentation Audio  
Financing the Neuroscience Pipeline from a VC Perspective Jonathan J. Fleming. Oxford Biosciences 24 min. 15 sec. Presentation Audio  
Resource Allocation in Translational Neuroscience: An Industry Perspective in 2009 Janet Vergis, A Division of Ortho-McNeil Janssen Pharmaceuticals 16 min. 9 sec. Presentation Audio  

Friday, March 6, 2009

Pharmacogentics: Implications for CNS Drug Development in the 21st Century

Title Speaker(s) Duration Presentation Audio Video
Genomic /Genetic Considerations in CNS Drug Development: Current Status and Approaches "1. Basic Science Standpoint" Orest Hurko, M.D., Wyeth Research 33 min. 31 sec. Presentation   Video
Pharmacogenomics: Implications for Clinical Education Howard J. Federoff, M.D., Ph.D., Georgetown University 26 min. 26 sec. Presentation   Video

Implications for Drug Development

Title Speaker(s) Duration Presentation Audio Video
Pharmacogenetics of Antipsychotic Drug Response Anil K. Malhotra, M.D., Albert Einstein Colllege of Medicine 28 min. 8 sec. Presentation   Video
Shedding Light on Restless Legs Syndrome via the Human Genome: Pharmacogenomic Implications David B. Rye, M.D., Emory Univeristy 29 min. 29 sec. Presentation   Video
Pharmacogenomics: Implications for CNS Drug Development in the 21st Century Valerie A. Cwik, M.D., Medical Director, Muscular Dystrophy Association (MDA)   Presentation   Video
Phamocogenetics Biomarkers "Dividing to Conquer" Cristina Sampaio M.D., Ph.D., The European Medicines Agency (EMEA)   Presentation    
Panel Discussion - Part 1 Panel 13 min. 36 sec.     Video
Panel Discussion - Part 2 Panel 8 min. 39 sec.     Video

Pipeline Projects - Alzheimer's Disease

Title Speaker(s) Duration Presentation Audio Video
Results of a Phase 2A Study of a Novel 5HT4 Agonist for the Treatment of Alzheimer's Disease J. Thomas Megerian, M.D., Ph.D., Epix Pharmaceuticals 7 min. 25 sec. Presentation   Video
Biomarkers for Monitoring Treatment with HDAC Inhibitors James Rusche, Ph.D., Repligen Corporation 10 min. 46 sec. Presentation   Video
ORM-12741 for Negative and Cognitive Symptoms of Schizophrenia, Depression and Alzheimer's Disease Juha Rouru, Ari Koivisto, Katja Kuokkanen, Jyrki Lehtimäki, Niina Jalava and Tiina Pirttilä, Orion Corporation, Orion Pharma 6 min. 18 sec. Presentation   Video
Phase 2 Trial of Tau Aggregation Inhibitor Therapy in Alzheimer's Disease Claude Wischik, Peter Bentham (PI), Roger Staff, Alison Murray, Donald Mowat, John Storey, Damon Wischik, University of Aberdeen & TauRx Therapeutics 10 min. 23 sec. Presentation   Video

Pipeline Projects - Neuropathic Pain & Migraine

Title Speaker(s) Duration Presentation Audio Video
YKP3089 - Novel Neurotherapeutic Martin Brecher, M.D., SK Life Sciences 4 min. 23 sec. Presentation   Video
Novel Development of IR Oxycodone HCl Tablets with Aversion® Technology Kenneth W Sommerville M.D., King Pharmaceuticals 11 min. 16 sec. Presentation   Video
MAP004 in Clinical Development: Novel and Optimized Delivery of DHE to the Lung Thomas Armer, M.D., MAP Pharmaceuticals 8 min. 16 sec. Presentation   Video
Safety and Tolerability of the MAO Inhibitor Isocarboxazid (Marplan) in the Prophylactic Treatment of Migraine Herbert Harris, M.D., Ph.D., Validus Pharmaceuticals 8 min. 19 sec. Presentation   Video

Pipeline Projects - Epilepsy

Title Speaker(s) Duration Presentation Audio Video
Retigabine Roger J. Porter, M.D., University of Pennsylvania 6 min. 11 sec. Presentation   Video
An Overview of the Development of Eslicarbazepine Acetate (ESL) as Adjunctive Therapy for Partial Seizures - A Novel Experimental Sodium Channel Blocker Mark Versavel, M.D., Ph.D., MBA, Sepracor Inc. 8 min. 20 sec. Presentation   Video
2DG - A Familiar Antiglycolytic Glucose-analog With Novel Anticonvulsant Properties Thomas Sutula, M.D., Ph.D., Department of Neurology, University of Wisconsin 13 min. 59 sec. Presentation   Video
The NeuroPace® RNS System: Clinical Development of Responsive Cortical Stimulation as a Treatment for Medically Refractory Epilepsy Martha J. Morrell M.D., NeuroPace, Inc. 9 min. 56 sec. Presentation   Video
Convection-Enhanced Delivery for the Treatment of Partial Seizures Michael A. Rogawski, M.D., Ph.D., University of Caifornia, Davis 15 min. 21 sec. Presentation   Video

Pipeline Projects - Movement Disorders & Neuromuscular

Title Speaker(s) Duration Presentation Audio Video
Selective Inhibitor of VMAT2 with an Attractive PK and Safety Profile for Hyperkinetic Movement Disorders Ajay Madan, Ph.D., Neurocrine Biosciences 7 min. Presentation   Video
Translational Neurobiology Application to Huntington's Diseases Therapeutics Development in Huntington's Disease: Targeting neurotrophin and Sirtuins Wenzhen Duan, M.D, Ph.D., Johns Hopkins University 10 min. 16 sec. Presentation   Video
Ataluren (PTC124TM) Leone Atkinson, M.D., Ph.D., PTC Therapeutics, Inc. 16 min. 49 sec. Presentation   Video

Pipeline Projects - Spinal Cord Injury/Multiple Sclerosis

Title Speaker(s) Duration Presentation Audio Video
Acorda Therapeutics: Preclinical Pipeline Anthony Caggiano, M.D., Ph.D., Acorda Therapeutics, Inc. 8 min. 49 sec. Presentation   Video

Pipeline Projects - Neuro-Oncology

Title Speaker(s) Duration Presentation Audio Video
New Peptide Engineered Compounds able to Cross the Blood-Brain Barrier to Treat Brain Diseases Reinhard Gabathuler, Ph.D., Angiochem Inc. 12 min. 41 sec. Presentation   Video

Pipeline Projects - Partnering with Large Pharma

Title Speaker(s) Duration Presentation Audio Video
Partnering with Eli Lilly and Company Mary Chamberlain-Tharp, Ph.D., MBA, Eli Lilly and Company 7 min. 49 sec. Presentation   Video

Saturday, March 7, 2009

The Role of Neuroimaging in Clinical Trials and Drug Discovery

Title Speaker(s) Duration Presentation Audio Video
The Neuroimaging Technology Revolution Rohit Bakshi, M.D., FAAN, Brigham & Women's Hospital, Harvard Medical School   Presentation    
Chasing Down New Treatments Walter Koroshetz, M.D., National Institute of Neurological Disorders and Stroke   Presentation    
Use of Magnetic Resonance Imaging In Multiple Sclerosis Trials Richard A. Rudick, M.D., Cleveland Clinic   Presentation    
The Role of Neuroimaging in Therapeutic Trials and Drug Discovery: Alzheimer’s Disease Joseph C. Masdeu, M.D., Ph.D., National Institute of Mental Health/NIH   Presentation    
The Role of Neuroimaging in Clinical Trials and Drug Discovery In Psychiatry Joseph C. Masdeu, M.D., Ph.D., National Institute of Mental Health/NIH   Presentation    
Panel Discussion Panelist 32 min. 58sec.      

Clinical Trials in Neurotherapeutics

Title Speaker(s) Duration Presentation Audio Video
Overview of Phase I->Phase III Fundamentals of Clinical Trials Roger J. Porter, M.D., University of Pennsylvania 39 min. 39 sec. Presentation Audio  
Clinical Trial Timelines Cornelia Kamp, MBA., Univeristy of Rochester 40 min. 1 sec. Presentation Audio  
Subject Recruitment & Retention Joyce A. Cramer, Epilepsy Therapy Project 36 min. 52 sec. Presentation Audio  
Handling (and Preventing) Missing Data in RCTs Janet Wittes, Ph.D., President, Statistics Collaborative 41 min. 27 sec. Presentation Audio  
Biomarkers and Surrogates: Underpinnings and Clinical Trial Applications Marc K. Walton, M.D., Ph.D., FDA 42 min. 51 sec. Presentation Audio  
International Clinical Trials - A Regulatory Perspective James Ottinger, R.Ph, Vice President, Global Consulting and Compliance, Premier Research 32 min. 19 sec. Presentation Audio  
Ethical Issues in Clinical Trials of Neurotherapeutics Scott Kim, M.D., Ph.D., Assistant Professor of Psychiatry, Univeristy of Michigan 32 min. 6 sec. Presentation Audio