ASENT Posters

To drive scientific progress in neurotherapeutics, the ASENT annual meeting features poster sessions and pipeline presentations. These sessions connect experts from across disease states, disciplines, geographic boundaries and hail from industry, academia, government and advocacy. Research presented at ASENT is disseminated globally via the prestigious Neurotherapeutics Journal and through innovative digital media. See posters below

ASENT Pipeline Presentations

The Abstract Review Committee accepted 20 presentations which were delivered at the ASENT2020 Annual Meeting. Each presenter was provided 5 minutes to present. 

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EFFECTS OF VILOXAZINE ON CENTRAL NEUROTRANSMITTER SYSTEMS: A MICRODIALYSIS STUDY IN FREELY MOVING RATS

EFFECTS OF VILOXAZINE ON CENTRAL NEUROTRANSMITTER SYSTEMS: A MICRODIALYSIS STUDY IN FREELY MOVING RATS

Chungping Yu, PhD; Jennie Garcia-Olivares, PhD; Stefan Schwabe, MD, PhD; Supernus Pharmaceuticals

Abstract:SPN-812 (viloxazine extended release) is currently under investigation as a treatment for ADHD. In recently completed Phase 3 trials, SPN-812 was effective in reducing symptoms of hyperactivity, impulsivity, and inattention in ADHD. Historical data has shown that viloxazine has an inhibitory effect on norepinephrine uptake. Recently, we had used microdialysis to further elucidate the activity of viloxazine in central neurotransmitter systems. In this study, extracellular levels of neurotransmitters were measured in the prefrontal cortex (PFC), nucleus accumbens (NAcc), and amygdala (AMG) of freely moving rats before and after a single administration of viloxazine (50 mg/kg, IP) or vehicle. Dialysate concentrations of norepinephrine (NE), dopamine (DA), serotonin (5-HT), gamma-aminobutyric acid (GABA), glutamate (Glu), histamine (His), and acetylcholine (ACh) were measured using LC-MS. Results indicated that viloxazine increased 5-HT, NE, and DA levels up to 506, 650, and 670% of baseline levels, respectively, in the PFC. No significant changes in the levels of GABA, Glu, His, or ACh were observed in the PFC. In the NAcc, an increase in 5-HT levels up to 365% of baseline were observed. An approximate 190% increase in NE and DA were also noted in the NAcc. Viloxazine also increased NE up to 571% in the AMG, along with increased levels of 5-HT (312%) and DA (254%). Vehicle injection produced no significant effects on the levels of all evaluated neurotransmitters in PFC, NAcc, and AMG. The observed upregulation of extracellular 5-HT in PFC, an established target area associated with ADHD pathophysiology, demonstrates viloxazine’s modulatory effect on serotonergic system. The ability of viloxazine to increase NE and DA in PFC confirms its inhibitory activity on the norepinephrine transporter. Minimal increases of DA in the NAcc indicates that viloxazine presents a low risk for substance abuse disorders. SPN-812 has recently been submitted to the FDA for approval.

Presented by:
Chungping Yu, PhD

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Institution/Company:
Supernus Pharmaceuticals

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Hashtags:
#ASENT2020 #Neurotransmitter #ADHD #Supernus

EFFECTS OF VILOXAZINE ON CENTRAL NEUROTRANSMITTER SYSTEMS: A MICRODIALYSIS STUDY IN FREELY MOVING RATS

Chungping Yu, PhD; Jennie Garcia-Olivares, PhD; Stefan Schwabe, MD, PhD; Supernus Pharmaceuticals

Abstract:Lorem ipsum dolor sit amet, consectetur adipiscing elit. Curabitur nulla ligula, viverra nec augue egestas, lobortis volutpat dolor. Morbi eget lorem nec libero fermentum rutrum. In ac accumsan sem, eu mattis ex. Maecenas molestie erat lacus, sed elementum dolor imperdiet sed. Integer volutpat facilisis vulputate. Integer elementum mauris laoreet gravida euismod. Ut tellus est, ullamcorper quis bibendum id, dapibus ac quam. Curabitur in dui commodo, faucibus urna sed, ultrices sem. Pellentesque habitant morbi tristique senectus et netus et malesuada fames ac turpis egestas. Fusce dolor lectus, rhoncus eu molestie vel, vehicula sed eros. Sed ligula massa, elementum ac mauris rutrum, sagittis tincidunt arcu. Sed cursus nisi nec orci rhoncus placerat. Etiam sed mollis turpis, pharetra consequat enim.

Presented by:
Chungping Yu, PhD

Connect with Presenter

Institution/Company:
Supernus Pharmaceuticals

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Hashtags:
#ASENT2020 #Neurotransmitter #Supernus

A detailed analysis of multiple imagery sources for a typical adult male Homo sapiens

Godfrey Hounsfield, Allan McLeod Cormack, Wilhelm C Röntgen

AbstractVestibulum ante ipsum primis in faucibus orci luctus et ultrices posuere cubilia Curae; Nam erat sapien, vulputate non augue nec, dapibus imperdiet neque. Nullam tempor placerat feugiat. Donec ut ultricies elit. Morbi quis gravida erat, et dignissim purus. Vestibulum porttitor eros nec ex vehicula, vitae dictum justo imperdiet. Quisque maximus, erat ut vulputate venenatis, eros velit efficitur lorem, ut venenatis ipsum dolor in justo. Ut eu orci eu elit eleifend ullamcorper. Curabitur maximus venenatis finibus. Nulla facilisi.
Presented byGodfrey Hounsfield <godfrey@example.com>
InstitutionDepartment of Anatomical Sciences,
University of Sometown Somewhere

Available from 9:30-11:15am today.

Hashtags#fake2020 #imaging #ctscan #xrays #oldschool

A detailed analysis of multiple imagery sources for a typical adult male Homo sapiens

Godfrey Hounsfield, Allan McLeod Cormack, Wilhelm C Röntgen

AbstractVestibulum ante ipsum primis in faucibus orci luctus et ultrices posuere cubilia Curae; Nam erat sapien, vulputate non augue nec, dapibus imperdiet neque. Nullam tempor placerat feugiat. Donec ut ultricies elit. Morbi quis gravida erat, et dignissim purus. Vestibulum porttitor eros nec ex vehicula, vitae dictum justo imperdiet. Quisque maximus, erat ut vulputate venenatis, eros velit efficitur lorem, ut venenatis ipsum dolor in justo. Ut eu orci eu elit eleifend ullamcorper. Curabitur maximus venenatis finibus. Nulla facilisi.
Presented byGodfrey Hounsfield <godfrey@example.com>
InstitutionDepartment of Anatomical Sciences,
University of Sometown Somewhere

Available from 9:30-11:15am today.

Hashtags#fake2020 #imaging #ctscan #xrays #oldschool

A detailed analysis of multiple imagery sources for a typical adult male Homo sapiens

Godfrey Hounsfield, Allan McLeod Cormack, Wilhelm C Röntgen

AbstractVestibulum ante ipsum primis in faucibus orci luctus et ultrices posuere cubilia Curae; Nam erat sapien, vulputate non augue nec, dapibus imperdiet neque. Nullam tempor placerat feugiat. Donec ut ultricies elit. Morbi quis gravida erat, et dignissim purus. Vestibulum porttitor eros nec ex vehicula, vitae dictum justo imperdiet. Quisque maximus, erat ut vulputate venenatis, eros velit efficitur lorem, ut venenatis ipsum dolor in justo. Ut eu orci eu elit eleifend ullamcorper. Curabitur maximus venenatis finibus. Nulla facilisi.
Presented byGodfrey Hounsfield <godfrey@example.com>
InstitutionDepartment of Anatomical Sciences,
University of Sometown Somewhere

Available from 9:30-11:15am today.

Hashtags#fake2020 #imaging #ctscan #xrays #oldschool

A detailed analysis of multiple imagery sources for a typical adult male Homo sapiens

Godfrey Hounsfield, Allan McLeod Cormack, Wilhelm C Röntgen

AbstractVestibulum ante ipsum primis in faucibus orci luctus et ultrices posuere cubilia Curae; Nam erat sapien, vulputate non augue nec, dapibus imperdiet neque. Nullam tempor placerat feugiat. Donec ut ultricies elit. Morbi quis gravida erat, et dignissim purus. Vestibulum porttitor eros nec ex vehicula, vitae dictum justo imperdiet. Quisque maximus, erat ut vulputate venenatis, eros velit efficitur lorem, ut venenatis ipsum dolor in justo. Ut eu orci eu elit eleifend ullamcorper. Curabitur maximus venenatis finibus. Nulla facilisi.
Presented byGodfrey Hounsfield <godfrey@example.com>
InstitutionDepartment of Anatomical Sciences,
University of Sometown Somewhere

Available from 9:30-11:15am today.

Hashtags#fake2020 #imaging #ctscan #xrays #oldschool

A detailed analysis of multiple imagery sources for a typical adult male Homo sapiens

Godfrey Hounsfield, Allan McLeod Cormack, Wilhelm C Röntgen

AbstractVestibulum ante ipsum primis in faucibus orci luctus et ultrices posuere cubilia Curae; Nam erat sapien, vulputate non augue nec, dapibus imperdiet neque. Nullam tempor placerat feugiat. Donec ut ultricies elit. Morbi quis gravida erat, et dignissim purus. Vestibulum porttitor eros nec ex vehicula, vitae dictum justo imperdiet. Quisque maximus, erat ut vulputate venenatis, eros velit efficitur lorem, ut venenatis ipsum dolor in justo. Ut eu orci eu elit eleifend ullamcorper. Curabitur maximus venenatis finibus. Nulla facilisi.
Presented byGodfrey Hounsfield <godfrey@example.com>
InstitutionDepartment of Anatomical Sciences,
University of Sometown Somewhere

Available from 9:30-11:15am today.

Hashtags#fake2020 #imaging #ctscan #xrays #oldschool